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Botox, Dysport, Xeomin — What’s the Difference?

Know the Difference Among Injectable FillersWhen you think of an injectable that works by preventing certain facial muscles from moving, Botox may spring to mind right away. But Botox is just a particular brand of neuromodulator, which reduces the appearance of lines and wrinkles by preventing muscle movements. There are two other products, Dysport and Xeomin, that contain a similar ingredient, botulinum toxin, and work in a similar way.

While the three products are similar, they aren’t identical. There are a few key differences among them. Your plastic surgeon can help you decide which is the right one for you, depending on whether you’re looking to ease the appearance of crow’s feet, frown lines or other dynamic wrinkles.

How They Work

Botox, Dysport and Xeomin are all designed to do the same thing. Each injectable is commonly used to treat wrinkles that form as a result of facial muscle movements, also called dynamic wrinkles. Once injected, the botulinum toxin prevents the nerves from sending signals to the muscles. A surgeon will usually use a very fine needle to inject the product into the facial muscles. Typically, treatment takes less than 20 minutes,  no matter which of the three brands are used.

FDA Approval

One big difference among the three types of botulinum injections is when they were approved by the FDA for use in the United States. Botox is the grandfather of injections, as it was approved by the FDA for use on the glabellar lines, or frown lines, back in 2002. The FDA also approved Botox for use on crow’s feet in 2013.

Dysport was used throughout Europe for years before being approved in the US. The FDA granted approval in 2009. It approved Xeomin for a similar purpose in 2011.


The remaining differences between Xeomin, Dysport and Botox are very subtle. The three products tend to produce results at different rates. Unlike injectable fillers, which provide immediate results, neuromodulators need time to work. Dysport may be the quickest of the three, producing results after just a couple of days. Often, it takes Botox about a week to show results. The results from Xeomin can appear after three days, but may take as long as seven to show up.
Results from each product last for about the same amount of time, anywhere from three to four months. To maintain results, your surgeon might recommend having another injection every three to four months.


All three products are formulated slightly differently. It’s thought that the different formulations of Dysport and Xeomin might make it less likely for a person to develop a resistance to the product over time. But, resistance to Botox is itself very rare, so that impact of the different formula might be minimal.

Both Xeomin and Dysport contain fewer proteins than Botox. Xeomin is "naked," meaning it has no proteins and contains just the botulinum toxin. Since Xeomin doesn’t contain any proteins, the body is less likely to produce antibodies in response to it.


Dysport seems to be a little thinner and more likely to spread once injected than Botox. It’s thinner consistency can be both positive and negative. It is a benefit when the product is injected into a larger area. But, it can be a drawback if the injector needs to place Dysport in a very specific region. Having the substance spread to other areas of the face increases the risk for side effects, such as drooping eyelid.

No Matter Which You Choose

One thing the three have in common is the requirement that they be injected by a person who’s been trained and who has experience. If a surgeon only has experience with or training in Botox injections and you are considering Xeomin, you’ll want to find someone who has training and experience with Xeomin. The dosing requirements are slightly different for each product. Plus, since each is slightly different in terms of consistency and spread, the injector needs to know how to position the injection and how much to use to get the desired results.

Each of the three has similar risks and recovery requirements. In the majority of cases, you’ll be back on your feet and back to your regular life almost right away. There is the chance of mild side effects, such as redness or bruising, after any injection. It should fade within a few days and not get in the way of your regular life.

At Clevens Face and Body Specialists, nationally recognized facial plastic surgeon Dr. Ross Clevens performs Dysport, Botox and Xeomin injections. If you are concerned about lines and wrinkles on your face, call (321) 727-3223 today to schedule an appointment with Dr. Clevens.

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Dr Clevens | Melbourne, FL

Dr. Ross Clevens, 707 W Eau Gallie Blvd. Melbourne, FL 32935 | (321) 727-3223

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